Surgery: Forskolin, a chemical found in coleus, might increase bleeding during and after surgery. Technical production of RA in cell cultures of C. blumei could be economically feasible. View abstract. Briq. However, currently there is no reliable scientific information that shows Coleus extracts taken by mouth are effective. It is perennial. Coleus Forskohlii is a plant. The synthesis of forskolin seems to be coupled to some state of differentiation; however, this correlation is not as strict as in other systems, where absolutely no secondary compounds are formed in undifferentiated cells. Medicinal coleus (Coleus forskohlii Briq) Liliaceae. Acute effects of topical forskolin on aqueous humor dynamics in man. The low water solubility to forskolin has made a direct application of forskolin impossible. Bentham (1832-1836) considered these two plants as different species and placed them into the genus Coleus, with the names C. blumei and C. scutellarioides. Crop thrives best in areas receiving 70 cm annual rainfall. View abstract. When inhaled, coleus can cause throat irritation, cough, tremor, and restlessness. These flowers are mostly blue or lilac-blue and grow in terminal spikelike racemes or panicles. Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy. This plant is native to areas in the lower elevations of India. Medicinal coleus (Coleus forskohlii) is an important medicinal crop which contains forskolin in their roots. Lebedinsky, Y., Nordstrom, S. T., Aschoff, S. E., Kapples, J. F., O'Malley, G. J., Kosley, R. W., Jr., Fielding, S., and Hubbard, J. W. Cardiotonic and coronary vasodilator responses to milrinone, forskolin, and analog P87-7692 in the anesthetized dog. When taken by mouth, coleus is used to treat allergies , dry eye, skin conditions such as eczema and psoriasis , obesity , painful menstrual periods, irritable bowel syndrome ( IBS ), urinary tract infections ( UTI ), bladder infections, advanced cancer , blood clots , sexual problems in men, trouble sleeping ( insomnia ), and convulsions . Cahn, D., Melman, A., Valcic, M., and Christ, G. J. Forskolin: a promising new adjunct to intracavernous pharmacotherapy. View abstract. A high amount of rosmarinic acid is accumulated in only a few days at the end of the growth phase of the cell cultures. The genus Coleus was first described by de Loureiro in 1790. Zeng, S., Shen, B., Wen, L., Hu, B., Peng, D., Chen, X., and Zhou, W. Experimental studies of the effect of Forskolin on the lowering of intraocular pressure. View abstract. J Ocul.Pharmacol 1989;5(3):181-187. 1998;93 Suppl 1:66-75. Eur J Pharmacol 1985;111:1-8. - Herbal Medicine - An illustrated compilation of Philippine medicinal plants by Dr Godofredo Umali Stuart with botanical information, chemical properties, folkloric uses and medicinal research studies. Coleus's basic cardi ovascular action is to lower blood Caprioli J, Sears M, Bausher L, et al. View abstract. Nevertheless, numerous publications on this species use the name C. blumei, namely, reports on the production of rosmarinic acid by this species. J Int Med Res. Yang, Q. R., Wu, H. Z., Wang, X. M., Zou, G. A., and Liu, Y. W. Three new diterpenoids from Coleus forskohlii Briq. eMedicineHealth does not provide medical advice, diagnosis or treatment. 1986;281(1):110-119. Medicinal use was mapped to the Paton et al. View abstract. 1995;11(3):173-176. View abstract. However, RA-producing cell cultures of C. blumei have become a useful system for basic research concerning the regulation of secondary product biosysnthesis. Significance of plasma adenosine in the antiplatelet activity of forskolin: potentiation by dipyridamole and dilazep. View abstract. J Cardiovasc Pharmacol 1990;16:93-100. View abstract. Arzneimittelforschung 1978;28(2):284-289. A comparative study with dobutamine and sodium nitroprusside. Rosmarinic acid is found not only in the plant, but is also produced in undifferentiated cell cultures which even have a much higher content. The highest forskolin production in tissue and organ cultures was in about the same range as in the plant material. Planta Med 1985;6:473-7. View abstract. Inhibition of hepatic metastasis from a human pancreatic adenocarcinoma (RWP-2) in the nude mouse by prostacyclin, forskolin, and ketoconazole. ... if rather terse, guide to the traditional medicinal uses of the plants of the region, 1346. Panminerva Med. 2012;54(1 Suppl 4):77-82. 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